Terpenoids as Potential Geroprotectors

Terpenoids as potential anti-Alzheimer's disease therapeutics.

Alzheimer's disease (AD) is one of the most well-known neurodegenerative diseases and explains 50-60% of dementia in patients. The prevalence rate of AD is positively correlated with age and AD affects ≥ 40% of those over 85 years old. The major AD therapeutics available on the market are acetylcholinesterase inhibitors, such as tacrine and donepezil. New therapeutic agents that can block the d...

Geroprotectors: Anti-Aging Molecules

Potential of Terpenoids and Flavonoids from Asteraceae as Anti-Inflammatory, Antitumor, and Antiparasitic Agents

1Departamento de Farmacologı́a, Cátedra de Farmacognosia, Facultad de Farmacia y Bioquı́mica, Universidad de Buenos Aires, Buenos Aires, Argentina 2Universidad de Buenos Aires, CONICET, Instituto de Quı́mica y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina 3Instituto de Fisiologı́a Animal, Fundación Miguel Lillo y Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nac...

Terpenoids: Higher

Terpenoids (synonymous with isoprenoids or isopentenoids) are a diverse class of natural products that are derived biosynthetically from an intermediate with a simple five-carbon skeleton (isopentane); higher terpenoids are complex structures that possess minimally between 20 and 40 carbon atoms. Higher terpenoids evolved coincidentally with the evolution of life and play multiple functions in ...

Geroprotectors: A Unified Concept and Screening Approaches

Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific community. Such concept as a system of criteria for geroprotector identificatio...